Statistical Optimization of Biomass and Extracellular Polysaccharide Production by the Wild Helvella lacunosa Mycelium in Liquid-State Fermentation Using a Pine Needles Extract Medium

The objective of this study was Toys using a statistical model to optimize the medium formula and liquid culturing conditions, which was employed to evaluate the potency of pine needles extract as nutritional component in basal medium for culturing Helvella lacunose in order to enhancing the production of mycelia and extracellular polysaccharides (

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Comparison of drug safety data obtained from the monitoring system, literature, and social media: An empirical proof from a Chinese patent medicine.

OBJECTIVES:To investigate the consistency of adverse events (AEs) and adverse drug reactions (ADRs) reported in the literature, monitoring and social media data.METHODS:Using one Chinese patent medicine-Cordyceps sinensis extracts (CSE) as an example, we obtained safety data from the national monitoring system (July 2002 to February 2016), literatu

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Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy

Abstract Background One of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance.Taking BRAF-mutant melanoma as paradigm, we previously identified the lipogenic regulator SREBP-1 as a central mediator of resistance to MAPK-targeted therapy.Reasoning that lipogenesis-mediated alterations in membrane lipid poly-uns

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